Dr. Elzbieta Brzuszkiewicz Postdoc
Address
Georg-August University of Göttingen   Institute of Microbiology and Genetics   Department of Genomic and Applied Microbiology   Grisebachstr. 8, 37077 Göttingen, Germany
Office
Room: 3.126
Tel: ++49 (0)551 39
E-Mail: ebrzusz(at)gwdg.de

Research Project(s)

• Epidemiologie und Systembiologie des pathogenen Bakteriums Clostridium difficile

Publications

Brüggemann H, Poehlein A, Brzuszkiewicz E, Scavenius C, Enghild JJ, Al-Zeer MA, Brinkmann V, Jensen A, Söderquist B (2019) Staphylococcus saccharolyticus isolated from blood cultures and prosthetic joint infections exhibits excessive genome decay. Front Microbiol 10:478 (doi:10.3389/fmicb.2019.00478).

Brüggemann H, Jensen A, Nazipi S, Aslan H, Meyer RL, Poehlein A, Brzuszkiewicz E, Al-Zeer MA, Brinkmann V, Söderquist B (2018) Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors. Sci Rep 8:266 (doi:10.1038/s41598-017-18661-8).

Brüggemann H, Migliorini LB, Oliveira de Sales R, Mariko Koga PC, de Souza AV, Jensen A, Poehlein A, Brzuszkiewicz E, Doi AM, Pasternak J, Martino MDV, Severino P (2018) Comparative genomics of non-outbreak Pseudomonas aeruginosa strains underlines genome plasticity and geographic relatedness of the global clone ST235. Genome Biol Evol 10(7):1852-1857 (doi:10.1093/gbe/evy139).

Groß U, Brzuszkiewicz E, Gunka K, Starke J, Riedel T, Bunk B, Spröer C, Wetzel D, Poehlein A, Chibani C, Bohne W, Overmann J, Zimmermann O, Daniel R, Liesegang H (2018) Comparative genome and phenotypic analysis of three Clostridioides difficile strains isolated from a single patient provide insight into multiple infection of C. difficile. BMC Genomics 19:1 (doi:10.1186/s12864-017-4368-0).

Davidsson S, Carlsson J, Mölling P, Gashi N, Andren O, Andersson S-O, Brzuszkiewicz E, Poehlein A, Al-Zeer M, Brinkmann V, Scavenius C, Nazipi S, Söderquist B, Brüggemann H (2017) Prevalence of Flp pili-encoding plasmids in Cutibacterium acnes isolates obtained from prostatic tissue. Front Microbiol 8:2241 (doi:10.3389/fmicb.2017.02241).

Hollensteiner J, Wemheuer F, Harting R, Kolarzyk A, Verlerio-Diaz S, Poehlein A, Brzuszkiewicz E, Nesemann K, Braus-Stromeyer S, Braus G, Daniel R, Liesegang H (2017) Bacillus thuringiensis and Bacillus weihenstephanensis inhibit the growth of phytopathogenic Verticillium species. Front Microbiol 7:2171 (doi:10.3389/fmicb.2016.02171).

Christensen GJ, Scholz CF, Enghild J, Rohde H, Kilian M, Thürmer A, Brzuszkiewicz E, Lomholt HB, Brüggemann H (2016) Antagonism between Staphylococcus epidermis and Propionibacterium acnes and its genomic basis. BMC Genomics 17:152 (doi:10.1186/s12864-016-2489-5).

Müller WJ, Tlalajoe N, Cason ED, Litthauer D, Reva O, Brzuszkiewicz E, van Heerden E (2016) Whole genome comparison of Thermus sp. NMX2.A1 reveals principle carbon metabolism differences with closest relation Thermus scotoductus SA-01. G3 6(9):2791-2797 (doi:10.1534/g3.116.032953).

Brüggemann H, Brzuszkiewicz E, Chapeton-Montes D, Plourde L, Speck D, Popoff MR (2015) Genomics of Clostridium tetani. Res Microbiol 166:326-331 (doi:10.1016/j.resmic.2015.01.002).

Huja S, Oren Y, Trost E, Brzuszkiewicz E, Biran D, Blom J, Goesmann A, Gottschalk G, Hacker J, Ron EZ, Dobrindt U (2015) Genomic avenue to avian colisepticemia. mBio 6(1):e01681-14 (doi:10.1128/mBio.01681-14).

Lück C, Brzuszkiewicz E, Rydzewski K, Koshkolda T, Sarnow K, Essig A, Heuner K (2015) Subtyping of the Legionella pneumophila "Ulm" outbreak strain using the CRISPR-Cas system. Int J Med Microbiol 305:828-837 (doi:10.1016/j.ijmm.2015.08.001).

Masri L, Branca A, Sheppard AE, Papkou A, Laehnemann D, Guenther PS, Prahl S, Saebelfeld M, Hollensteiner J, Liesegang H, Brzuszkiewicz E, Daniel R, Michiels NK, Schulte RD, Kurtz J, Rosenstiel P, Telschow A, Bornberg-Bauer E, Schulenburg H (2015) Host-pathogen coevolution: the selective advantage of Bacillus thuringiensis virulence and its cry toxin genes. PLoS Biol 13:e1002169 (doi:10.1371/journal.pbio.1002169).

Riedel T, Bunk B, Thürmer A, Spröer C, Brzuszkiewicz E, Abt B, Gronow S, Liesegang H, Daniel R, Overmann J (2015) Genome resequencing of the virulent and multidrug-resistant reference strain Clostridium difficile 630. Genome Announc 3(2):e00276-15 (doi:10.1128/genomeA.00276-15).

Djukic M, Brzuszkiewicz E, Fünfhaus A, Voss J, Gollnow K, Poppinga L, Liesegang H, Garcia-Gonzalez E, Genersch E, Daniel R (2014) How to kill the honey bee larva: genomic potential and virulence mechanisms of Paenibacillus larvae. PLOS One 9(3):e90914 (doi:10.1371/journal.pone.0090914).

Brzuszkiewicz E, Schulz T, Rydzewski K, Daniel R, Gillmaier N, Dittmann C, Holland G, Schunder E, Lautner M, Eisenreich W, Lück C, Heuner K (2013) Legionella oakridgensis ATCC 33761 genome sequence and phenotypic characterization reveals its replication capacity in amoebae. Int J Med Microbiol 303(8):514-528 (doi:10.1016/j.ijmm.2013.07.003).

Eidam C, Poehlein A, Brenner Michael G, Kadlec K, Liesegang H, Brzuszkiewicz E, Daniel R, Sweeney MT, Murray RC, Watts JL, Schwarz S (2013) Complete genome sequence of Mannheimia haemolytica strain 42548 from a case of bovine respiratory disease. Genome Announc 1(3):e00318-13 (doi:10.1128/genomeA.00318-13).

Mak TN, Schmid M, Brzuszkiewicz E, Zeng G, Meyer R, Sfanos KS, Brinkmann V, Meyer TF, Brüggemann H (2013) Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria. BMC Genomics 14:640 (doi:10.1186/1471-2164-14-640).

Brzuszkiewicz E, Waschkowitz T, Wiezer A, Daniel R (2012) The complete genome sequence of the B12-producing Shimwellia blattae strain DSM 4481 isolated from a cockroach. J Bacteriol 194(16):4436 (doi:10.1128/JB.00829-12).

Michael GB, Kadlec K, Sweeney MT, Brzuszkiewicz E, Liesegang H, Daniel R, Murray RW, Watts JL, Schwarz S (2012) ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: structure and transfer. J Antimicrob Chemother 67(1):91-100 (doi:10.1093/jac/dkr411).

Michael GB, Kadlec K, Sweeney MT, Brzuszkiewicz E, Liesegang H, Daniel R, Murray RW, Watts JL, Schwarz S (2012) ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: analysis of the regions that comprise 12 antimicrobial resistance genes. J Antimicrob Chemother 67(1):84-90 (doi:10.1093/jac/dkr406).

Bijtenhoorn P, Mayerhofer H, Müller-Dieckmann J, Utpatel C, Schipper C, Hornung C, Szesny M, Grond S, Thürmer A, Brzuszkiewicz E, Daniel R, Dierking K, Schulenburg H, Streit WR (2011) A novel metagenomic short-chain dehydrogenase/reductase attenuates Pseudomonas aeruginosa biofilm formation and virulence on Caenorhabditis elegans. PLoS ONE 6(10):e26278 (doi:10.1371/journal.pone.0026278).

Bletz S, Schuldes J, Brzuszkiewicz E, Daniel R, Gottschalk G, Karch H, Mellmann A (2011) Evolutionary events in enterohemorrhagic Escherichia coli (EHEC) O26:H11. Int J Med Microbiol 301:(Supplement 47):115

Brzuszkiewicz E, Thürmer A, Schuldes J, Leimbach A, Liesegang H, Meyer FD, Boelter J, Petersen H, Gottschalk G, Daniel R (2011) Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC). Arch Microbiol 193(12):883-891 (doi:10.1007/s00203-011-0725-6).

Brzuszkiewicz E, Weiner J, Wollherr A, Thürmer A, Hüpeden J, Lomholt HB, Kilian M, Gottschalk G, Daniel R, Mollenkopf H-J, Meyer TF, Brüggemann H (2011) Comparative genomics and transcriptomics of Propionibacterium acnes. PLoS ONE 6:e21581 (doi:10.1371/journal.pone.0021581).

Duda KA, Lindner B, Brade H, Leimbach A, Brzuszkiewicz E, Dobrindt U, Holst O (2011) The lipopolysaccharide of the mastitis isolate Escherichia coli strain 1303 comprises a novel O-antigen and the rare K-12 core type. Microbiology 157(Pt6):1750-1760 (doi:10.1099/mic.0.046912-0).

Fekete PZ, Brzuszkiewicz E, Blum-Oehler G, Olasz F, Szabo M, Gottschalk G, Hacker J, Nagy B (2011) DNA sequence analysis of the composite plasmid pTC conferring virulence and antimicrobial resistance for porcine enterotoxigenic Escherichia coli. Int J Med Microbiol 302(1):4-9 (doi:10.1016/j.ijmm.2011.07.003).

Gounder K, Brzuszkiewicz E, Liesegang H, Wolherr A, Daniel R, Gottschalk G, Reva O, Kumwenda B, Srivastava M, Bricio C, Berenguer J, van Heerden E, Litthauer D (2011) Sequence of the hyperplastic genome of the naturally competent Thermus scotoductus SA-01. BMC Genomics 12(1):577 (doi:10.1186/1471-2164-12-577).

Kadlec K, Brenner Michael G, Sweeney MT, Brzuszkiewicz E, Liesegang H, Daniel R, Watts JL, Schwarz S (2011) Molecular basis of macrolide, triamilide and lincosamide resistance in Pasteurella multocida from bovine respiratory disease. Antimicrob Ag Chemoth 55:2475-2477 (doi:10.1128/AAC.00092-11).

Rechnitzer H, Brzuszkiewicz E, Strittmatter A, Liesegang H, Lysnyansky I, Daniel R, Gottschalk G, and Rottem S (2011) Genomic features and insights into the biology of Mycoplasma fermentans. Microbiology 157:760-773 (doi:10.1099/mic.0.043208-0).

Klee SR, Brzuszkiewicz EB, Nattermann H, Brüggemann H, Dupke S, Wollherr A, Franz T, Pauli G, Appel B, Liebl W, Couacy-Hymann E, Boesch C, Meyer FD, Leendertz FH, Ellerbrok H, Gottschalk G, Grunow R, Liesegang H (2010) The genome of a Bacillus isolate causing anthrax in chimpanzees combines chromosomal properties of B. cereus with B. anthracis virulence plasmids. PLoS One 5(7):e10986 (doi:10.1371/journal.pone.0010986).

Leimbach A, Brzuszkiewicz E, Thürmer A, Daniel R, Gottschalk G, Dobrindt U (2010) Elucidation of the complete genome sequence of Escherichia coli acute bovine mastitis isolate 1303: implications for host-pathogen interactions. Reprod Dom Anim 45: (Supplement 1):29

Zdziarski J, Brzuszkiewicz E, Wullt B, Liesegang H, Biran D, Voigt B, Grönberg-Hernandez J, Hecker M, Ron E, Daniel R, Gottschalk G, Hacker J, Svanborg C, Dobrindt U (2010) Host imprints on bacterial genomes - rapid, divergent evolution in individual patients. PLoS Pathogens 6(8):e1001078 (abstract)

Brzuszkiewicz E, Gottschalk G, Ron E, Hacker J, Dobrindt U (2009) Adaptation of pathogenic E. coli to various niches: genome flexibility is the key. Genome Dyn 6:110-125 (doi:10.1159/000235766).

Brzuszkiewicz E, Brüggemann H, Liesegang H, Emmerth M, Olschlager T, Nagy G, Albermann K, Wagner C, Buchrieser C, Emody L, Gottschalk G, Hacker J, Dobrindt U (2006) How to become an uropathogen: Comparative genomic analysis of extraintestinal pathogenic Escherichia coli strains. Proc Natl Acad Sci USA 103(34):12879-12884 (doi:10.1073/pnas.0603038103).

Hochhut B, Wilde C, Balling G, Middendorf B, Dobrindt U, Brzuszkiewicz E, Gottschalk G, Carniel E, Hacker J (2006) Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536. Mol Microbiol 61(3):584-595 (doi:10.1111/j.1365-2958.2006.05255.x).

Nougayrede JP, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E (2006) Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 313(5788):848-851 (doi:10.1126/science.1127059).

Wyszynska A, Pawlowski M, Bujnicki J, Pawelec D, Van Putten JP, Brzuszkiewicz E, Jagusztyn-Krynicka EK (2006) Genetic characterisation of the cjaAB operon of Campylobacter coli. Pol J Microbiol 55(2):85-94 (abstract)