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Last update: 04 Aug 2017
Workshop on Genomics & Bioinformatics [July 2017]
The 5th 'International Workshop on Prokaryotic Genomics & Bioinformatics' took place from 18-21 July 2017 (→ read more)
Joining ERA-IB consortium MetaCat [January 2017]
Since January 2017 our department belongs to the MetaCat consortium - a metagenomic collection of novel and highly efficient biocatalysts for industrial biotechnology (→ read more)
New OBAC cluster funded within ERA-IB [November 2016]
Partners form Frankfurt, Ulm, La Coruna, Gent and Göttingen will work together within the joint project 'OBAC - Overcoming energetic barriers in acetogenic conversion of carbon dioxide'. (→ read more)
FLEXIZUCKER - new BMEL funded project [October 2016]
Process engineering, enzymatic and genomic characterization of a flexible biogas production with targeted use of sugar beets (→ read more)
Annual Genomics Workshop [July 2016]
The 4th 'International Workshop on Prokaryotic Genomics & Bioinformatics' took place from 19-22 July 2016. (→ read more)

News (Archive)

› Annual Genomics Workshop [July 2016] (→ read more)
› CDiff project elongation until 2018 [July 2016] (→ read more)
› ANTIRES - new joint project [June 2016] (→ read more)
› ProkaGENOMICS 2015 conference [Oct 2015] (→ read more)
› iGEM Team Göttingen 2015 [September 2015] (→ read more)
› Annual Genomics Workshop [July 2015] (→ read more)
› RETROBIO - Successful project application within ERASynBio [March 2015] (→ read more)
› Annual Genomics Workshop [July 2014] (→ read more)
› BEFmate - new joint project [March 2014] (→ read more)
› 'Roseobacter'-SFB verlängert [November 2013] (→ read more)
› Norddeutscher Wissenschaftspreis 2013 verliehen [November 2013] (→ read more)
› Annual Genomics Workshop [October 2013] (→ read more)
› CDiff: Start of 3.9 Million Euro project [August 2013] (→ read more)
› ERA-IB 3 consortium has started work [May 2013] (→ read more)
› Forschungsprojekt: Europäische Faulbrut bei Bienen [4. April 2013] (→ read more)
› Ministerin Wanka eröffnet neues Genomik-Zentrum [11. Januar 2013] (→ read more)
› New multilateral research project within ERA-IB [December 2012] (→ read more)
› New DFG Priority Programme: Ecosystem Nutrition [May 2012] (→ read more)
› Next Polarstern trip started in March (Puntas Arenas, Chile) [March 2012] (→ read more)
› SFB 990 (Sumatra) started / Project B02 [January 2012] (→ read more)
› Two Co-Workers left for Polarstern trip (Cape Town, South Africa) [December 2011] (→ read more)
› Not EHEC, but rather EAHEC [June 2011] (→ read more)

Not EHEC, but rather EAHEC (June 2011)
Scientists at the University of Göttingen have decoded the genetic information of the Escherichia coli (E. coli O104:H4) bacterium, which causes the so-called EHEC infection. The Roche 454 sequencing technology was used to sequence the genomes of two isolates that were derived from two patients in Hamburg. “The results allow an important insight as to why this bacterium, which is particularly rampant in northern Germany, is so aggressive”, says Dr. Rolf Daniel, director of the Göttingen Genomics Laboratory.
EAHEC sequences (ftp server; user: EAHEC_GOS; password: EAHEC_GOS)

The sequence data indicate that the patient's isolates probably did not arise from an EHEC pathogen, but rather from a germ called EAEC (entero-aggregative Escherichia coli). This germ is able to attach particularly strongly to the epithelium. It then forms cell aggregates and initiates its normal, pathological programme. More than 96 percent of the genetic material of the Hamburg isolates are identical to that of an EAEC strain. The pathological potential of the EAEC germ has increased significantly by acquiring a special gene from other E. coli strains, such as EHEC, by means of bacterial viruses (phages) and integrating it into its own chromosome. This gene produces the so-called Shiga toxin, which originates from the pathogen causing shigellosis. It is a toxin which may trigger the haemolytic uraemic syndrome (HUS), namely blood decomposition, as well as complications, such as renal failure. This combination makes the bacterium dangerous: Its cells probably form large plaques in the intestine by attaching and aggregating, and this cell mass then produces a highly active poison. In addition, a so-called resistance plasmid protects the germ from a wide spectrum of antibiotics.

Scientists at the University of Göttingen have proposed the term ‘EAHEC’ (Entero-Aggregative-Haemorrhagic Escherichia coli) for the new pathotype.

Scientific publication:
Brzuszkiewicz E, Thürmer A, Schuldes J, Leimbach A, Liesegang H, Meyer F-D, Boelter J, Petersen H, Gottschalk G, and Daniel R (2011). Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC). Arch Microbiol 193:883-891 (abstract).

Modell of the formation of the new Entero-Aggregative Haemorrhagic Escherichia coli (EAHEC):