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Last update: 04 Aug 2017

Workshop on Genomics & Bioinformatics [July 2017]
The 5th 'International Workshop on Prokaryotic Genomics & Bioinformatics' took place from 18-21 July 2017 (→ read more)
Joining ERA-IB consortium MetaCat [January 2017]
Since January 2017 our department belongs to the MetaCat consortium - a metagenomic collection of novel and highly efficient biocatalysts for industrial biotechnology (→ read more)
New OBAC cluster funded within ERA-IB [November 2016]
Partners form Frankfurt, Ulm, La Coruna, Gent and Göttingen will work together within the joint project 'OBAC - Overcoming energetic barriers in acetogenic conversion of carbon dioxide'. (→ read more)
FLEXIZUCKER - new BMEL funded project [October 2016]
Process engineering, enzymatic and genomic characterization of a flexible biogas production with targeted use of sugar beets (→ read more)
Annual Genomics Workshop [July 2016]
The 4th 'International Workshop on Prokaryotic Genomics & Bioinformatics' took place from 19-22 July 2016. (→ read more)

Research project:

- funded by the BMBF in the framework of the ERASynBio initiative

The 1st joint call for proposals of ERASynBio was launched in May 2013 under the ERA-NET Scheme of the Seventh Framework Programme (FP7) of the European Commission. The call for proposals resulted in 55 proposals. After the assessment of an international Expert Evaluation Panel, the ERASynBio Call Group has selected 8 projects for funding.

RETROBIO Partners:
ETH Zürich - Prof. Sven Panke (Co-ordinator)
University of Basel - Prof. Florian Seebeck
University of Göttingen - Prof. Rolf Daniel
Graz University of Technology - Prof. Rolf Breinbauer

Project description:
We retrosynthetically designed a pathway along a completely novel set of new-to-nature metabolites for the synthesis of biotin, a high-value-added commercially relevant product currently manufactured by a chemical synthesis. The pathway will be implemented using rational design approaches complemented by advanced high throughput screening methods for the reprogramming of the substrate specificities of known enzymes. The project aims to demonstrate that multi-step biopathway design largely outside of the scope of reactions already known in nature is possible and provides attractive solutions to some of synthetic biology’s currently most intractable synthetic problems. Furthermore, we will demonstrate experimentally that retrosynthetic design is an excellent basis for rational biopathway design.
We expect the results to be a milestone in the demonstration of the potential of synthetic biology for the development of chemical syntheses, which hopefully encourages the more frequent application of biosynthesis as an alternative to chemical methods.

For more details on the ERASynBio initiative see erasynbio.eu

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