Dr. Robert HertelPostdoc
| Georg-August University of Göttingen|
Institute of Microbiology and Genetics
Department of Genomic and Applied Microbiology
Grisebachstr. 8, 37077 Göttingen, Germany
|Tel: ++49 (0)551 39 91120|
|Fax: ++49 (0)551 39 12181|
|03/2015 - present||Postdoc, Department of Genomic and Applied Microbiology of Prof. Dr. Rolf Daniel, University of Göttingen|
|10/2010 - 02/2015||Dissertation in the group of Dr. Heiko Liesegang, University of Göttingen|
|07/2009 - 03/2010||Diploma thesis (equivalent to Master thesis) in the group of Prof. Dr. Jörg Stülke, University of Göttingen|
|10/2006 - 03/2007||Erasmus Semester, University of Murcia, Spain|
|10/2004 - 03/2010||Study of Biology, Georg-August University Göttingen, Germany|
Major Research Interests
- Synthetic Biology: Making a shortcut in the pathway: synthetic biology meets metagenomics
E. coli synthesizes biotin with low efficiency through many reactions steps. In this project we postulate that the synthesis of Biotin should be possible by three reactions based on synthetic substrates. With metagenomic techniques we are searching for those needed biocatalysts to join them to a synthetic pathway and enable a microbial biotin production based on synthetic precursors (→ read more).
- Phage biology: What is out there: investigating phage diversity based on Bacillus subtilis
Bacteriophages are viruses of bacteria. In this project we like to explore the abundance, as well as the morphological and genetically diversity of phages from differed habitats infecting the soil bacterium Bacillus subtilis. The findings should lead to a better understanding of phage biology and will serve as a source of information for phage based applications.
- Shapeshifter: Prophages of Vibrio and their impact on host properties
Phages are more than killers. Some can reside in the genome of their bacterial hosts and influence its physiological abilities, like resistance to other phages, chemical compounds, or even expanding its metabolic capacity. Together with our cooperation partner at the GEOMAR we investigate prophages of over 70 marine Vibrio isolates to find out how they contribute to strain specific properties.
- RETROBIO: A twofold retrosynthetic implementation of a novel biochemical pathway, a synthetic route to biotin
Schilling T, Hoppert M, Daniel R, Hertel R (2018) Complete genome sequence of vB_BveP-Goe6, a virus infecting Bacillus velezensis FZB42. Genome Announc 6(8):e00008-18 (abstract).
Schilling T, Dietrich S, Hoppert M, Hertel R (2018) A CRISPR-Cas9-based toolkit for fast and precise in vivo genetic engineering of Bacillus subtilis phages. Viruses 10(5):241 (abstract).
Singh N, Herbig E, Hertel R (2018) Enzyme aus der Natur - Reinstwasser als Grundlage für Metagenomik. GIT-Labor 06.03.2018 (abstract).
Egelkamp R, Schneider D, Hertel R, Daniel R (2017) Nitrile-degrading bacteria isolated from compost. Front Env Sci 5:56 (abstract).
Hertel R, Meyerjürgens S, Voigt B, Liesegang H, Volland S (2017) Small RNA mediated repression of subtilisin production in Bacillus licheniformis. Sci Rep 7:5699 (abstract).
Wendling CC, Piecyk A, Refardt D, Chibani C, Hertel R, Liesegang H, Bunk B, Overmann J, Roth O (2017) Tripartite species interaction: eukaryotic hosts suffer more from phage susceptible than from phage resistant bacteria. BMC Evol Biol 17(1):98 (abstract).
Willms IM, Hoppert M, Hertel R (2017) Characterization of Bacillus subtilis viruses vB_BsuM-Goe2 and vB_BsuM-Goe3. Viruses 9(6):146 (abstract).
Wilms IM, Hertel R (2016) Phage vB BsuP-Goe1: the smallest identifed lytic phage of Bacillus subtilis. FEMS Microbiol Lett 363:fnw208 (abstract).
Hertel R, Volland S, Liesegang H. (2015) Conjugative reporter system for the use in Bacillus licheniformis and closely related Bacilli. Lett Appl Microbiol. 60(2):162-167 (abstract).
Hertel R, Rodríguez DP, Hollensteiner J, Dietrich S, Leimbach A Hoppert M, Liesegang H, Volland S (2015) Genome-based identification of active prophage regions by Next Generation Sequencing in Bacillus licheniformis DSM13. PLOS One 10(3):e0120759 (abstract).
Wiegand S, Dietrich S, Hertel R, Bongaerts J, Evers S, Volland S, Daniel R, Liesegang H (2013) RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation. BMC Genomics 14:667 (abstract).