|Joining ERA-IB consortium MetaCat [January 2017]|
|Since January 2017 our department belongs to the MetaCat consortium - a metagenomic collection of novel and highly efficient biocatalysts for industrial biotechnology (→ read more)|
|New OBAC cluster funded within ERA-IB [November 2016]|
|Partners form Frankfurt, Ulm, La Coruna, Gent and Göttingen will work together within the joint project 'OBAC - Overcoming energetic barriers in acetogenic conversion of carbon dioxide'. (→ read more)|
|FLEXIZUCKER - new BMEL funded project [October 2016]|
|Process engineering, enzymatic and genomic characterization of a flexible biogas production with targeted use of sugar beets (→ read more)|
|Annual Genomics Workshop [July 2016]|
|The 4th 'International Workshop on Prokaryotic Genomics & Bioinformatics' took place from 19-22 July 2016. (→ read more)|
|CDiff project elongation until 2018 [July 2016]|
|A research co-operation of microbiologists from northern Germany analyses the hospital-aquired pathogen Clostridium difficile in order to develop new diagnostic tools and therapies. (→ read more)|
Bacillus Genomics & Evolution
The genus Bacillus consists of a variety of species, including industrial applied saprophytes and fatal pathogens. Despite the adaptation to completely different habitats a substantial number of the genomes are conserved [Figure 1].
Figure 1: Biblast and sRNAfinder analysis of five selected Bacillus genomes.
The genomic circles demonstrate conserved chromosomal proteins and small RNAs on a (a) B. licheniformis DSM13 and (b) B. anthracis Ames Ancestor centered view. The outer rings depict the proteins of the query organisms, color coded for the direction of transcription. The second ring shows query organisms specific regions, which represent prophages and IS-elements. Prophages are explicitly marked. The four inner rings show the genomes of the hit organisms. Conserved proteins are depicted in red, small RNAs in blue and missing genes in grey. The inner rings show the GC-skew. The genomes used in the BiBaG comparisons are B. licheniformis DSM13, B. subtilis 168, B. amyloliquefaciens FZB42, B. cereus E33L and B. anthracis Ames Ancestor. In the sRNAfinder analysis of B. licheniformis DSM13 the chromosomes of B. subtilis 168, B. amyloliquefaciens FZB42 and B. anthracis Ames Ancestor have been used as references.
Based on the complete genome sequences of B. licheniformis , B. amyloliquefaciens  and B. cereus biovar anthracis  all sequenced by the Göttingen Genomics Laboratory - we focus our work on central topics of Bacillus evolution. Based on functional and comparative genomics we address the questions:
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 Klee SR, Brzuszkiewicz EB, Nattermann H, Brüggemann H, Dupke S, Wollherr A, Franz T, Pauli G, Appel B, Liebl W, Couacy-Hymann E, Boesch C, Meyer FD, Leendertz FH, Ellerbrok H, Gottschalk G, Grunow R, Liesegang H (2010) The genome of a Bacillus isolate causing anthrax in chimpanzees combines chromosomal properties of B. cereus with B. anthracis virulence plasmids. PLoS One. 5(7):e10986 (abstract).
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